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Year : 2021  |  Volume : 25  |  Issue : 2  |  Page : 124-128

Microneedling with topical 5-fluorouracil in the localized stable vitiligo – Is this the way out? – Our experience: A hospital-based study

1 Sparsh Skin Clinic, Jaipur, Rajasthan, India
2 Department of Skin and V.D., Sardar Patel Medical College, Bikaner, Rajasthan, India
3 Gheesibai Memorial Mittal Hospital and Research Centre, Ajmer, Rajasthan, India
4 Department of Skin and V.D., Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India
5 Department of Health and Family Welfare, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Paras Choudhary
9/20, Vidyadhar Nagar, Jaipur, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jdds.jdds_35_21

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Background: Vitiligo is a dermatological challenge with a major socio-psychological concern. Despite the availability of numerous medical and surgical treatment options, a single universally reliable therapeutic modality is yet to emerge due to the variability of response rate in different patients. Purpose: The objective of this study was to assess the safety and efficacy of microneedling along with topical 5-fluorouracil (5-FU) solution application in localized stable vitiligo. Methods: This open, nonrandomized, single-arm study was enrolled with 100 patients with localized stable vitiligo. Microneedling with topical 5-FU solution application was performed on 204 patches. The procedure was performed fortnightly for maximum 6 months. Results: At the end of 3 months, good to excellent (Grade IV) repigmentation was noted in 106 patches (51.96%) and Grade I to Grade II repigmentation was seen in 56 (27.45%) patches whereas at the end of follow-up, 128 (62.74%) patches showed good to excellent response. Conclusion: In conclusion, the results of this study showed that needling with 5-FU is a simple, cost-effective, and well-tolerated procedure which can be used as an alternative or additive modality in the treatment of localized stable vitiligo.

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