Autologous platelet-rich fibrin membrane as a wound dressing in the treatment of chronic nonhealing leg ulcers: A prospective study

Amina Asfiya; Sacchidanand Sarvajnamurthy; Fardeen Shariff; Leelavathy Budamakuntala

doi:10.4103/jdds.jdds_80_20

Users Online: 118

ORIGINAL ARTICLE

Year : 2022 \| Volume : 26 \| Issue : 2 \| Page : 73-76

Autologous platelet-rich fibrin membrane as a wound dressing in the treatment of chronic nonhealing leg ulcers: A prospective study Amina Asfiya¹, Sacchidanand Sarvajnamurthy², Fardeen Shariff³, Leelavathy Budamakuntala⁴ ¹ Department of Dermatology, Yenepoya Medical College, Deralakatte, Mangalore, Karnataka, India ² Senior Consultant Dermatologist, Sujala Polyclinic and Lab, Bengaluru, Karnataka, India ³ Department of Orthopaedics, Yenepoya Medical College, Deralakatte, Mangalore, Karnataka, India ⁴ Department of Dermatology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India Correspondence Address: Dr. Amina Asfiya Department of Dermatology, Venereology and Leprosy, Yenepoya Medical College, Deralakatte, Mangalore - 575 016, Karnataka India Source of Support: None, Conflict of Interest: None DOI: 10.4103/jdds.jdds_80_20

Background: Chronic nonhealing ulcers of the lower extremity are a cause of morbidity and mortality. The various treatment options available are limited and unsatisfactory. Promoting wound healing with an autologous platelet membrane could be a safe, easy, and inexpensive modality. Purpose: To assess an autologous platelet-rich fibrin (PRF) membrane as a wound dressing in the treatment of chronic nonhealing leg ulcers. Methods: A prospective study enrolled 30 patients with chronic nonhealing leg ulcers. Autologous PRF was applied weekly for 6 weeks. At each visit, the ulcer healing was assessed with wound measurements and photographs. The treatment outcome was defined as a percentage in a change of area and volume of the ulcer at the end of the study period. Results: Thirty patients with chronic nonhealing leg ulcers were treated for 6 weeks. 100% improvement in area of the ulcer was seen in 43% ulcers. The mean percentage of improvement in area of the ulcer was 72%. The mean percentage of improvement in volume of the ulcer was 77%. The mean duration of healing was 5 weeks. Conclusion: This study was limited by the lack of a control group. Autologous PRF may be useful for the treatment of chronic nonhealing leg ulcers which can be done on an outpatient basis with minimum adverse effects.



[FULL TEXT] [PDF]*

Table of Contents

Similar in PUBMED

Search Pubmed for

Search in Google Scholar for

Related articles

Citation Manager

Access Statistics

Reader Comments

Email Alert *

Add to My List *

* Requires registration (Free)

Article Access Statistics

Viewed	299

Printed	10

Emailed	0

PDF Downloaded	44

Comments	[Add]